evaluation of anti-candida properties of cationic peptides derived from rana ridibunda skin

background: antimicrobial peptides with relative length (2-100 amino acids) and positive charge (pure charge (+9)-(+2)) are amphiphilic that isolated from a wide range of animals. recently, these peptides have been known as a part of innate immune response. nowadays, more than 500 antimicrobial peptides from animals have been reported. objectives: the aim of this study was to evaluate the anti-candida effects of cationic peptides derived from rana ridibunda skin. methods: in this study, using alcohol-acid technique, peptides of frog’s skin were isolated and purified by sep-pack and sephadex column. then the anti-candida activity (fluconazole resistance c. albicans, fluconazole sensitive c. albicans, and c. glabrata) of the peptides in different concentrations were evaluated. results: regarding to statistical analysis, peptides in concentration ranging from 25 to 100 µg/ml had the most anti-candida activities. in respect to different understudy candida species, these agents had the less effect on the fluconazole resistance c. albicans (p